Kalki 2898 AD boasts a large ensemble cast. Besides Prabhas, the film features top stars Deepika Padukone, Amitabh Bachchan, Disha Patani, and Kamal Haasan in lead roles.
Important roles are also played by actors such as Malavika Nair, Anna Ben, and Shobana.
Additionally, five well-known celebrities make special guest appearances in the film: Vijay Deverakonda, Dulquer Salmaan, Mrunal Thakur, Rajamouli, and Ram Gopal Varma.
The three-hour-long film includes many actors in both minor and major roles, but the central plot revolves around Prabhas and Amitabh Bachchan.
The legendary Bollywood actor appears from the first to the final episode, while Kamal Haasan features only in the final minutes.
Deepika Padukone has an equally important role. The film includes only two songs: one duet featuring Prabhas and Disha Patani, and the other titled "Theme of Kalki."